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DeCS

Descriptor English:

Complement Factor H

Descriptor Spanish:

Factor H de Complemento

Descriptor Portuguese:

Fator H do Complemento

Synonyms English:

Factor H
Factor H, Complement

Tree Number:

Definition English:

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

Pharmacological Action:

History Note English:

93; was COMPLEMENT FACTOR H (NM) 1978-92

Allowable Qualifiers English:

Record Number:

30775

Unique Identifier:

D017242

Similar:

DeCS